カンザスシティ・ロイヤルズ

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Prof.  Tomomi Tsunematsu Tohoku Univ.Database--> Title Elucidation of sleep shift mechanism using misfolding proteins that mimic aging Priod 2020-2021 The quality of sleep and biological rhythm change with age. However, the detail mechanism in still unknown. For example, it remains unclear that why aging cause reduction of deep non-REM sleep, fragmentation of sleep, and keeping early hours. Aging-induced defects are also evident in various misfolding disease states such as diabetes and neurodegenerative disorders. Especially in Japan, where aging is becoming more serious, it is estimated that the population with dementia will reach approximately 7 million by 2025, which is equivalent to one in five people over the age of 65. This is one of the targets of Japan as it confronts the problems of a super-aging society. In this study, we focus on mis-folding proteins that cause aging-related neurodegenerative diseases and make an attempt to quantify the alteration in sleep quality associated with brain damage. We explore new theory regarding “various aging-related disorders and sleep”. Ultimately, our research will create highly novel value and build treatment strategies for related diseases, thus contributing to healthy longevity.   PAGE TOP Frontier Research Institute for Interdisciplinary Sciences About FRIS GreetingsOverviewMissionsOrganizationTenure track system in FRISMaps & DirectionsPublicationAnnual MeetingConsultation Desk Researcher Advanced Interdisciplinary Research DivisionCreative Interdisciplinary Research DivisionManaging & Planning DivisionEndowed Research DivisionsSenior-advisorVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time members Feature TopicsFRIS InterviewsFRIS Hub Meeting Research Programs Open Research ProposalResearch Projects Recruit Open Staff PositionsHandbook for International Researchers FRIS CoRE FRIS CoRE FRIS Fund FRIS Fund for Early-Career Independent Researchers External Links for Early Career Researcher Support Division for Interdisciplinary Advanced Research and Education (DIARE) Ensemble Project for Early Career Researchers Support Program for the Article Processing Charge webmail LINK Copyrights © Frontier Research Institute for Interdisciplinary Sciences, Tohoku University All rights reserved. no cache