ジェフリージョン・ウルフ

DSpace Softwareについて English   検索 詳細検索 ホーム   ブラウズ コミュニティ/コレクション 発行日 著者 タイトル 主題   アクセス状況 アイテム別 高頻度ダウンロード文献 アクセス統計   登録利用者: 購読情報編集   ヘルプ DSpaceについて GINMU > 01 奈良県立医科大学 > 012 大学院 > 0122 学位請求論文 > 01221 博士論文（医学） > 2023年度 > このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/4236 タイトル: Neovascularization From the Carotid Artery Lumen Into the Carotid Plaque Confirmed by Contrast-Enhanced Ultrasound and Histology その他のタイトル: 血管内腔側から流入する頚動脈プラーク内新生血管の造影超音波及び病理学的検討 著者: Uchihara, YutoSaito, KozueMotoyama, RieIshibashi-Ueda, HatsueYamaguchi, ErikoHatakeyama, KintaTanaka, AkitoKataoka, HiroharuIihara, KojiSugie, KazumaKoga, MasatoshiToyoda, KazunoriNagatsuka, KazuyukiIhara, Masafumi キーワード: AtherosclerosisNeovascularizationContrast-enhancedultrasound 発行日: 2023年8月 出版者: Elsevier Inc. 引用: Ultrasound in Medicine & Biology. 2023 Aug, vol.49, No.8, p.1798-1803 抄録: Objective: This study was aimed at assessing intraplaque neovessels, focusing on neovascularization from the vascular luminal side using contrast-enhanced ultrasound (CEUS) and determining that this contrast effect indicates that the neovessel is connected to the vessel lumen histopathologically. Whether plaque vulnerability can be assessed more accurately was also investigated. Methods: We enrolled consecutive patients with internal carotid artery stenosis who underwent carotid endarterectomy (CEA) and pre-operative CEUS with perflubutane of the carotid arteries. We graded the contrast effect semi-quantitatively from the vascular luminal and adventitial sides. We compared the contrast effect with the pathological findings, especially the neovascularization of the CEA specimens. Results: In total, 68 carotid arterial atheromatous plaques (47 symptomatic) were analyzed. Symptomatic plaques were significantly correlated with stronger contrast effects from the luminal side than from the adventitial side (p = 0.0095). Microbubbles from the luminal side appeared to flow mainly into the plaque shoulder. The contrast effect value for the plaque shoulder and neovessel density were significantly correlated (ρ = 0.35, p = 0.031). Neovessel density was significantly higher in symptomatic than in asymptomatic plaques (56.2 ± 43.7/mm2 and 18.1 ± 15.2/mm2, respectively, p < 0.0001). Serial histological sections of CEA specimens in a symptomatic plaque with a strong contrast effect from the luminal side revealed multiple neovessels fenestrated to the vessel lumen with endothelial cells, consistent with the CEUS findings. Conclusion: Contrast-enhanced ultrasound can be used to evaluate neovessels originating from the luminal side, histopathologically confirmed in serial sections. Symptomatic vulnerable plaque is correlated more significantly with intraplaque neovascularization from the luminal side than with neovascularization from the adventitia. 内容記述: 本文は発行元が定める公開猶予期間終了後に公開。 URI: http://hdl.handle.net/10564/4236 DOI: https://doi.org/10.1016/j.ultrasmedbio.2023.04.002 学位授与番号: 24601甲第892号 学位授与年月日: 2023-12-22 学位名: 博士（医学） 学位授与機関: 奈良県立医科大学 出現コレクション:2023年度 このアイテムのファイル: ファイル 記述 サイズフォーマット K892_abstract.pdf甲892論文内容の要旨64.77 kBAdobe PDF見る/開くK892_review.pdf甲892審査要旨204.91 kBAdobe PDF見る/開く このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。   Powered by DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - ご意見をお寄せください