プレイオジョでもらえる初回入金ボーナスを徹底解説【最新版】
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Academic Research Staff Details of a Researcher Home Japanese このページはJavascriptを使用しています。すべての機能を使用するためにはJavascript を有効にする必要があります。 Updated on 2024/04/04 Keyword・Affiliation・Field・Alphabetical Search Personnel Information Profile Degree Employment Record in Research Research Activity Papers Updated on 2024/04/04 IGIMI Sizunobu Professor Title Professor Contact information External Link To the head of this page.▲ Degree 【 display / non-display 】 To the head of this page.▲ Degree 【 display / non-display 】 農学博士 ( 1989.03 東京大学 ) To the head of this page.▲ Employment Record in Research 【 display / non-display 】 To the head of this page.▲ Employment Record in Research 【 display / non-display 】 Tokyo University of Agriculture Nodai Research Institute Professor 2023.04 - 2024.03 Tokyo University of Agriculture Nodai Research Institute Professor 2024.04 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Applied Biology and Chemistry Professor 2016.04 - 2018.03 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Agricultural Chemistry Professor 2018.04 - 2023.03 To the head of this page.▲ Papers 【 display / non-display 】 To the head of this page.▲ Papers 【 display / non-display 】 The Importance of the Validated Microbiological Test Method and Direction of Microbial Testing under HACCP Control Igimi Shizunobu Foods & Food Ingredients Journal of Japan 227 ( 1 ) 004 - 009 2022 More details Language:Japanese Publisher:Editorial Board of Foods & Food Ingredients Journal of Japan The importance of the validated microbiological test method and how to select the test method based on the fitness for purpose will be explained. Based on this, I will show how to select a microbial test method after the transition to process control such as the HACCP (Hazard Analysis and Critical Control Point), and how to utilize microbial test for risk management. DOI: 10.34457/ffij.227.1_004 CiNii Articles Studies on Epidemiology of Microorganisms Related to Human Health Disorders, and Their Control Japanese Journal of Food Microbiology 38 ( 2 ) 53 - 66 2021.06 More details Language:Japanese Publisher:Japanese Society of Food Microbiology DOI: 10.5803/jsfm.38.53 CiNii Articles Research on the safety of genetically modified foods led to the development of oral mucosal vaccines of Lactic Acid Bacteria. Igimi Shizunobu Japanese Journal of Lactic Acid Bacteria 32 ( 1 ) 7 - 14 2021.03 More details Language:Japanese Publisher:Japan Society for Lactic Acid Bacteria
Research on the safety of genetically modified foods began in 1989 by forming a research group with researchers from private dairy companies. The group contributed to the establishment of the Japan Society for Lactic Acid Bacteria academically and to the development of international guidelines on the safety of genetically modified foods administratively. The group needed a recombinant lactic acid bacterium as a model for safety evaluation, which was later expanded to recombinant vaccine development research.
Based on the previous studies of vaccination, we are recognized that the administration of a vaccine through the infection route of a pathogen is highly effective for vaccination. According to the concept, oral vaccination is the best strategy to induce both local mucosal and systemic immunity against mucosal infective type pathogens. Among several candidates of vaccine agents, Lactobacillus strains are particularly attractive as the antigen delivery vehicles because of the safeness and the adjuvanticity. we constructed recombinant Lactic Acid Bacteria expressing many kinds of protective antigens. Most successful vaccine has been established oral heat-killed vaccine for human papillomavirus
(HPV). As a result, high levels of HPV E7 specific cytotoxic T lymphocyte (CTL) were induced from the immunized both mice and human. Currently, human clinical trials are underway using this vaccine.
DOI: 10.4109/jslab.32.7 Construction of an in vitro human M cell model using RANKL Ono Tatsuya, Masuda Kazuya, Kajikawa Akinobu, Yokota Kenji, Igimi Shizunobu Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 ( 0 ) 1-O-G2-4 2021 More details Language:Japanese Publisher:Japanese Pharmacological SocietyIntestinal immunity is triggered mainly by M cells existing in the intestinal tract by uptake antigens to gut associated lymphoid tissue (GALT). Recently, it has been attracting attention as a target of oral vaccine. However, primary culture is difficult because the number of M cells in vivo is small. Therefore, an in vitro human M cell model that can evaluate vaccines targeting M cells is required. If an in vitro human M cell model is constructed, we thought that we could contribute to the development of targeted oral vaccines and basic research on the function of human M cells. We constructed an in vitro human M cell model and evaluated the uptake of bacteria using cultured cells. M cell model was constructed by using the co-cultured of C2BBe1 and Raji cells, in which C2BBe1 was cultivated on the cell insert membrane and Raji cells in the well. We attempted to construct a new model by adding GST-RANKL, in which GST tag attached to RANKL(receptor activator of NF-κB ligand), a protein involved in differentiation into M cells. After co-culture, the number of fluorescent beads that was uptake by M cell (a functional evaluation), and the expression level of the M cell marker sialyl Lewis A antigen were compared with the co-culture model. In both evaluations, the new model showed improvement compared to the co-culture model.
DOI: 10.1254/jpssuppl.94.0_1-o-g2-4 CiNii Articles Draft Genome Sequences of Non-H 2 S-Producing Strains of Salmonella enterica Serovars Infantis, Enteritidis, Berta, and Kiambu in Japan. Reviewed Asakura H, Sakata J, Yamamoto S, Igimi S. Microbiol Resour Announc. (2020) 9 ( 30 ) 2020.07 More details Authorship:Corresponding author Language:English Publishing type:Research paper (scientific journal) display all >> To the head of this page.▲ Copyright © TOKYO UNIVERSITY OF AGRICULTURE FOUNDED, All Rights Reserved.