ベガウォレット使い方
<ウェブサイト名>
<現在の時刻>
Researchers Details of a Researcher Home Japanese このページはJavascriptを使用しています。すべての機能を使用するためにはJavascript を有効にする必要があります。 Personnel Information Personnel Information Education Campus Career Professional Memberships Research Activity Papers Books MISC Presentations Industrial property rights Grant-in-Aid for Scientific Research Available Technology Updated on 2024/04/05 KAI Kengo Affiliation Faculty of Medicine School of Medicine Department of Anatomy, Histochemistry and Cell Biology Title Assistant Professor Laboratory Address 宮崎市清武町木原5200 Contact information External Link To the head of this page.▲ Education 【 display / non-display 】 To the head of this page.▲ Education 【 display / non-display 】 University of Tsukuba 2002.4 - 2008.4 To the head of this page.▲ Campus Career 【 display / non-display 】 To the head of this page.▲ Campus Career 【 display / non-display 】 University of Miyazaki Faculty of Medicine School of Medicine Department of Anatomy, Histochemistry and Cell Biology Assistant Professor 2024.04 - Now University of Miyazaki Faculty of Medicine College Hospital A Assistant Professor 2020.04 - 2024.03 To the head of this page.▲ Professional Memberships 【 display / non-display 】 To the head of this page.▲ Professional Memberships 【 display / non-display 】 日本光線力学学会 2019 日本組織細胞化学会 2019 日本内視鏡外科学会 2018 日本消化器病学会 2018 日本消化器内視鏡学会 2018 display all >> To the head of this page.▲ Papers 【 display / non-display 】 To the head of this page.▲ Papers 【 display / non-display 】 A Preliminary Pathological Evaluation of Extracellular Volume Fraction with Contrast-enhanced Computed Tomography as a Novel Quantitative Parameter of Pancreatic Fibrosis Reviewed Kai Kengo, Hiyoshi Masahide, Imamura Naoya, Hamada Takeomi, Yano Koichi, Sato Yuichiro, Sakae Takehumi, Komi Masanori, Nakamura Takashi, Choijookhuu Narantsog, Hishikawa Yoshitaka, Nanashima Atsushi Internal Medicine 62 ( 8 ) 1107 - 1115 2023 More details Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine Objective The extracellular volume (ECV) calculated based on contrast-enhanced computed tomography (CT) has been reported as a novel imaging parameter reflecting the morphological change of fibrosis in several parenchymal organs. Our retrospective study assessed the validity of the ECV fraction for diagnosing pancreatic fibrosis and the appropriate imaging condition as the "equilibrium phase". Methods In 27 patients undergoing multiphasic CT and subsequent pancreaticoduodenectomy, we investigated pathological fibrotic changes related to the ECV fraction and conducted analyses using the value obtained by subtracting the equilibrium CT value of the portal vein from that of the abdominal aorta (Ao-PVequilibrium) to estimate eligibility of the equilibrium phase. Results In all patients, the ECV fraction showed a weak positive correlation with the collagenous compartment ratio (r=0.388, p=0.045). All patients were divided into two groups - the high-Ao-PVequilibrium group and low-Ao-PVequilibrium group - based on the median value. No significant correlation was found in the high-Ao-PVequilibrium group, whereas a significant correlation was observed in the low-Ao-PVequilibrium group (r=0.566, p=0.035). Conclusion The ECV fraction is a possible predictive factor for histopathological pancreatic fibrosis. In its clinical application, the eligibility of the "equilibrium phase" may affect the diagnostic capability. It will be necessary to verify the imaging conditions in order to improve the accuracy of the diagnosis. DOI： 10.2169/internalmedicine.0410-22 Scopus PubMed CiNii Research An alternative option of the retroperitoneal laparoscopic approach for limited hepatectomy for recurrent hepatocellular carcinoma at the transected edge after previous hepatectomy. Reviewed Hamada T, Yano K, Kitamura E, Hiyoshi M, Imamura N, Kai K, Tahira K, Kawano F, Ohta Y, Nanashima A Asian journal of endoscopic surgery 16 ( 3 ) 567 - 570 2023.3 More details Language：English Publishing type：Research paper (scientific journal) Publisher：Asian Journal of Endoscopic Surgery Laparoscopic hepatectomy is safely performed with minimal invasiveness on patients with recurrent liver tumors after previous hepatectomy. However, it is still difficult to dissect and expose the operative field at the transected edge or plane after open right hepatectomy, even for limited resection by a laparoscopic approach, due to severe adhesion to the surrounding peritoneum or organs. We herein applied the retroperitoneal laparoscopic approach to limited resection of the dorsal surface at the transected edge of Couinaud&＃39;s segment 6 after previous repeated hepatectomies in a patient with recurrent hepatocellular carcinoma (HCC) by avoiding severe intra-abdominal adhesion. We safely resected recurrent HCC via the retroperitoneal space. This approach is a useful and alternative option for laparoscopy which minimizes the dissecting time and avoids organ injury on the right side of the transected area of the liver after hepatectomy in patients with liver malignancies. DOI： 10.1111/ases.13185 Scopus PubMed Correction: Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. Reviewed Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y Journal of ovarian research 16 ( 1 ) 21 2023.1 More details Language：English Publishing type：Research paper (scientific journal) DOI： 10.1186/s13048-023-01105-5 PubMed Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis Reviewed Kai K., Hamada T., Sato Y., Hiyoshi M., Imamura N., Yano K., Ikeda T., Ichihara A., Ogata S., Choijookhuu N., Hishikawa Y., Hosokawa A., Nanashima A. Journal of Oncology 2023 1440257 2023 More details Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Oncology Background. Oxaliplatin (OX)-based chemotherapy induces sinusoidal obstruction syndrome (SOS) in the nontumorous liver parenchyma, which can increase the risk of liver resection due to colorectal liver metastasis (CRLM). The extracellular volume (ECV) calculated from contrast-enhanced computed tomography (CT) has been reported to reflect the morphological change of hepatic fibrosis. The present retrospective study aimed to evaluate the ECV fraction as a predictive factor for OX-induced SOS. Methods. Our study included 26 patients who underwent liver resection for CRLM after OX-based chemotherapy with a preoperative dynamic CT of appropriate quality. We investigated the relationship between the pathological SOS grade and the ECV fraction. Results. Overall, 26 specimens from the patients were graded with the SOS classification of Rubbia-Brandt et al. as follows: grade 0, n = 17 (65.4%); grade 1, n = 4 (15.4%); and grade 2, n = 5 (19.2%). No specimens showed grade 3 SOS. In a univariate analysis, the ECV fraction in grade 0 SOS was significantly lower than that in grade 1 + 2 SOS (26.3 ± 3.4% vs. 30.6 ± 7.0%; P = 0.025). The cutoff value and AUC value of the ECV fraction to distinguish between grades 0 and 1 + 2 were 27.5% and 0.771, respectively. Conclusions. Measurement of the ECV fraction was found to be a potential noninvasive diagnostic method for determining early-stage histopathological sinusoidal injury induced by OX-based chemotherapy. DOI： 10.1155/2023/1440257 Scopus PubMed Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. Reviewed Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C, Hishikawa Y Journal of ovarian research 15 ( 1 ) 133 2022.12 More details Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Ovarian Research Background: High-Mobility Group Box 1 (HMGB1) and HMGB2 are chromatin-associated proteins that belong to the HMG protein family, and are involved in the regulation of DNA transcription during cell differentiation, proliferation and regeneration in various tissues. However, the role of HMGB2 in ovarian folliculogenesis is largely unknown. Methods: We investigated the functional role of HMGB1 and HMGB2 in ovarian folliculogenesis and fertilization using C57BL/6 wild type (WT) and HMGB2-knockout (KO) mice. Ovarian tissues were obtained from WT and HMGB2-KO mice at postnatal days 0, 3, 7, and 2, 6 months of age, then performed immunohistochemistry, qPCR and Western blotting analyses. Oocyte fertilization capability was examined by natural breeding and in vitro fertilization experiments. Results: In HMGB2-KO mice, ovary weight was decreased due to reduced numbers of oocytes and follicles. Natural breeding and in vitro fertilization results indicated that HMGB2-KO mice are subfertile, but not sterile. Immunohistochemistry showed that oocytes expressed HMGB2, but not HMGB1, in neonatal and adult WT ovaries. Interestingly, in HMGB2-KO ovaries, a compensatory increase in HMGB1 was found in oocyte nuclei of neonatal and 2-month-old mice; however, this was lost at 6 months of age. Conclusions: The depletion of HMGB2 led to alterations in ovarian morphology and function, suggesting that HMGB2 plays an essential role in ovarian development, folliculogenesis and fertilization. DOI： 10.1186/s13048-022-01071-4 Scopus PubMed display all >> To the head of this page.▲ Books 【 display / non-display 】 To the head of this page.▲ Books 【 display / non-display 】 GNSS software receivers Borre K. (Kai), Fernández-Hernández Ignacio, López-Salcedo José A., Bhuiyan M. Zahidul H.（ Role： Sole author） Cambridge University Press 2023 （ ISBN:9781108837019 ） More details Language：English CiNii Books Student engagement in the language classroom Hiver Phil, Al-Hoorie Ali H., Mercer Sarah（ Role： Sole author） Multilingual Matters 2021 （ ISBN:9781788923590 ） More details Language：English CiNii Books Student engagement in the language classroom Hiver Phil, Al-Hoorie Ali H., Mercer Sarah（ Role： Sole author） Multilingual Matters 2021 （ ISBN:9781788923606 ） More details Language：English CiNii Books To the head of this page.▲ MISC 【 display / non-display 】 To the head of this page.▲ MISC 【 display / non-display 】 Correction: Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility (Journal of Ovarian Research, (2022), 15, 1, (133), 10.1186/s13048-022-01071-4) Shirouzu S., Sugita N., Choijookhuu N., Yamaguma Y., Takeguchi K., Ishizuka T., Tanaka M., Fidya , Kai K., Chosa E., Yamashita Y., Koshimoto C., Hishikawa Y. Journal of Ovarian Research 16 ( 1 ) 21 2023.12 More details Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Journal of Ovarian Research Following publication of the original article [1], the uthors identified an error in authorgroup. Author name Fidya Fidya should be Fidya. The original article has been corrected. DOI： 10.1186/s13048-023-01105-5 Scopus PubMed Rare resected eight cases of duodenal adenocarcinomas Nanashima A., Tanoue Y., Imamura N., Hiyoshi M., Yano K., Hamada T., Nishida T., Kai K., Suzuki Y., Sato Y., Nakashima K., Hosokawa A., Nagayasu T. International Journal of Surgery Case Reports 86 106384 2021.9 More details Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：International Journal of Surgery Case Reports Introduction: Duodenal adenocarcinoma is a rare malignancy; recently, it has been found to be accompanied by operative indications. Methods: Nine consecutive rare cases were diagnosed with duodenal carcinoma (DC), in which clinicopathological characteristics were retrospectively examined. Age was ranged over middle-aged males and females. No clinical onset with severe symptoms was observed, and the specific treatment for accompanied diseases or habits was not found. Outcomes: One case of two T1 stage DCs that underwent pancreas-sparing duodenectomy. Stage II DC was diagnosed in three cases, and stage III DC was diagnosed in four cases. Pancreaticoduodenectomy (PD) mainly occurred in seven patients, and duodenectomy was limited in two patients. All operations were safely performed, and the postoperative course showed no severe morbidity. Histological findings showed R0 resection in eight cases and R1 at the retroperitoneal dissecting part in one case. Five patients with advanced-stage DC underwent adjuvant chemotherapy; however, four patients showed tumor recurrence within 12 months. With additional strong chemotherapy, eight patients survived up to 84 months, and one died of liver metastasis at 43 months after surgery. Three representative cases of mucosal invasion with widespread pancreas-sparing duodenectomy and advanced-stage DC cases undergoing duodenectomy or PD are shown. Conclusion: In the field of upper digestive tract surgery, duodenal adenocarcinoma and various applications of surgery or adjuvant chemotherapy for long-term survival are important. DOI： 10.1016/j.ijscr.2021.106384 Scopus PubMed To the head of this page.▲ Presentations 【 display / non-display 】 To the head of this page.▲ Presentations 【 display / non-display 】 A Clinicopathological Study of Extracellular Volume Fraction Determined by Contrast Enhanced Computed Tomography as a Predictive Factor of Pancreatic Fistula after Pancreaticoduodenectomy International conference Kai K, Hiyoshi M, Imamura N, Hamada T, Yano K, Sato Y, Sakae T, Choijookhuu N, Hishikawa Y, Nanashima A 15th IHPBA World Congress More details Event date： 2022.3.30 - 2022.4.2 Presentation type：Poster presentation 当院における妊娠合併虫垂炎に対する 腹腔鏡下虫垂切除術の経験と工夫 甲斐健吾，池田拓人，市原明子，河野文彰，濱田朗子，松澤聡，鮫島浩，七島篤志 第13回Acute care surgery学会学術集会 More details Event date： 2021.11.4 - 2021.11.27 Presentation type：Symposium, workshop panel (public) 膵頭十二指腸切除術における術後膵液漏の発生と造影CTによる細胞外血管外腔算出値の関連 甲斐健吾，旭吉雅秀，矢野公一，今村直哉，濱田剛臣，佐藤勇一朗，榮建文，七島篤志 JDDW 2021 KOBE More details Event date： 2021.11.4 - 2021.11.7 Presentation type：Oral presentation (general) 当科における大腸癌肝転移に対する初回肝切除の治療成績と血清CRP・アルブミン比の意義 甲斐健吾，濱田剛臣，池田拓人，市原明子，今村直哉，旭吉雅秀，内勢由佳子，原大介，鈴木康人，七島篤志 第46回日本大腸肛門病学会九州地方会 More details Event date： 2021.10.16 Presentation type：Symposium, workshop panel (public) 当院での経腹壁的エラストグラフィによる膵線維化診断能の病理学的検証 甲斐健吾，濱田剛臣，旭吉雅秀，矢野公一，今村直哉，佐藤勇一朗，河上洋，田島栄美，七島篤志 日本超音波医学会第31回九州地方会学術集会 More details Event date： 2021.10.3 Presentation type：Oral presentation (general) display all >> To the head of this page.▲ Industrial property rights 【 display / non-display 】 To the head of this page.▲ Industrial property rights 【 display / non-display 】 直腸固有筋膜近接神経検査方法、及び神経検査装置 甲斐 健吾 More details Applicant：宮崎大学 Application no：2022-100239 Date applied：2022.6.22 Announcement no：2024-001530 Date announced：2024.1.10 Country of applicant：Domestic To the head of this page.▲ Grant-in-Aid for Scientific Research 【 display / non-display 】 To the head of this page.▲ Grant-in-Aid for Scientific Research 【 display / non-display 】 食道癌に対する光線力学療法による薬剤耐性軽減効果の証明と新規治療開発に向けた検証 Grant number：20K17694 2020.04 - 2023.03 独立行政法人日本学術振興会 科学研究費補助金 若手研究 More details Authorship：Principal investigator To the head of this page.▲ Available Technology 【 display / non-display 】 To the head of this page.▲ Available Technology 【 display / non-display 】 低強度光線力学療法を用いた抗癌剤耐性の軽減効果の実証 Photodaynamic primingを用いた新規腹膜播種治療の開発 詳細を見る Related fields where technical consultation is available：培養細胞を用いた光線力学療法の実施 Message：臨床経験から着想を得た研究で、実現すれば多くの癌患者さんの助けになると考えています。少しでも前に進めていけるように、多分野から様々なアドバイスを頂ければと思い掲載を希望しました。 To the head of this page.▲ Copyright © University of Miyazaki. All Rights Reserved
